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  • 无菌室无菌环境的净化控制!
    来源:http://www.jnyhrs.com 浏览: 发布日期:2019-08-16
      无菌室无菌环境的质量控制对获得准确的微生物数据至关重要。
      Quality control of aseptic environment in aseptic room is very important for obtaining accurate microbial data.
      食品微生物检验对无菌环境和无菌操作有严格的要求。整个检测过程始终要求无菌操作在无菌状态下进行,因此无菌状态的质量控制是保证微生物检测结果准确可靠的保证。
      Food microbiological testing has strict requirements for aseptic environment and aseptic operation. The whole detection process always requires aseptic operation in aseptic state, so the quality control of aseptic state is the guarantee to ensure the accuracy and reliability of microbial detection results.
      操作人员应定期严格评估无菌室的消毒效果。同时,应该建立合理的环境监测程序,数据分析环境监测的结果应可接受不同工作区域的细菌菌落数量应严格按照相应的国家标准,并记录控制应超过标准的治疗。
      Operators should regularly and strictly evaluate the disinfection effect of sterile rooms. At the same time, reasonable environmental monitoring procedures should be established. Data analysis of environmental monitoring results should be acceptable. The number of bacterial colonies in different working areas should be strictly in accordance with the corresponding national standards, and records should be recorded to control the treatment exceeding the standard.
      此外,无菌室的环境,如温度和湿度,可能会影响消毒灭菌效果。一般温度控制在22℃左右,相对湿度不超过65%。
      In addition, the sterile room environment, such as temperature and humidity, may affect the disinfection and sterilization effect. Generally, the temperature is controlled at about 22 C, and the relative humidity is not more than 65%.
      整个无菌室应采用先进高效的层流空气净化系统,保证恒温、恒湿、通风、空气洁净的要求。空气净化系统中的高效过滤膜可以有效过滤空气中不同大小和规格的粉尘颗粒,防止附着在粉尘颗粒上的微生物污染无菌室。从顶部到底部的空气分布确保清洁和节约能源。
      The whole sterile room should adopt advanced and efficient laminar air purification system to ensure the requirements of constant temperature, humidity, ventilation and air cleanliness. The high efficiency filter membrane in the air purification system can effectively filter dust particles of different sizes and specifications in the air, and prevent microorganisms adhering to dust particles from polluting the sterile chamber. Air distribution from top to bottom ensures cleanliness and energy conservation.
      无菌室、人员通道、物流窗口安装紫外线杀菌灯,可对物品表面及空气进行消毒;工作时,风淋室的高效过滤空气可以吹掉一些附着在操作工工作服上的灰尘,物流窗口可以转移实验室用品和样品。所有这些设计都能保证无菌室的清洁。
    无菌室装修
      Ultraviolet bactericidal lamp is installed in sterile room, personnel passageway and logistics window, which can disinfect the surface of articles and air. When working, the highly efficient filtered air in the air shower room can blow off some dust attached to the operator's work clothes, and the logistics window can transfer laboratory supplies and samples. All these designs ensure the cleanliness of the sterile room.
      同时hepa过滤系统的风量可以满足人员的需要,更好的解决了传统无菌室无法替代新鲜洁净空气、工作环境差等问题。
      At the same time, the air volume of HEPA filter system can meet the needs of personnel, better solve the problems of traditional sterile room can not replace fresh and clean air, poor working environment and so on.
      此外,对无菌室的无菌程度应定期进行监测,可参照制药行业洁净室中粉尘颗粒、沉降菌、浮游菌等物品的限度,对食品微生物无菌室进行定期检测。
      In addition, the aseptic degree of the sterile room should be monitored regularly. According to the limits of dust particles, sedimentation bacteria and plankton bacteria in the clean room of pharmaceutical industry, the food microbial aseptic room can be detected regularly.
      解决的方法是最简单和直观的,能真正反映最表面(特别是控制区)的自然和污染特征,因此,也可以用平皿计数琼脂和孟加拉红琼脂板3块,等距离放置在一个无菌室工作位置在对角线上,打开暴露15分钟,分别在36℃培养48 h, 28℃培养5 d数结算后的细菌和霉菌和酵母数量的殖民地,如果菌落平均计数超过3 cfu/盘,应对无菌室内空气和表面进行消毒,以改善其无菌环境。
      The solution is the simplest and intuitive, which can truly reflect the nature and pollution characteristics of the most surface (especially the control area). Therefore, agar plate and Bangladesh red agar plate can also be counted with a dish. They can be placed at a diagonal working position in an aseptic chamber at equal distances, exposed for 15 minutes, incubated at 36 for 48 hours and incubated at 28 for 5 days. If the average count of bacteria, fungi and yeast exceeds 3 cfu/disc, the sterile indoor air and surface should be disinfected to improve the sterile environment.
      和微生物无菌室应制定有效的各种生物安全系统和严格执行,如与致病菌进入生物安全柜放置准备想要安装透明可见的玻璃门,门贴上相应的安全级别的“生物危害”图标,并清除附紧急联系人的联系方式。
      Effective biosafety systems and strict enforcement should be established in the microbial sterility room, such as putting pathogenic bacteria into the biosafety cabinet to install transparent and visible glass doors, pasting corresponding safety level "biological hazard" icons on the doors, and clearing contact information with emergency contacts.
      可自动关闭的专用垃圾桶应放置在不同区域,并在物流窗口等有紫外线照射的区域贴上“室内紫外线消毒灯”等警示标签。
      Special garbage cans that can be automatically closed should be placed in different areas, and warning labels such as "indoor ultraviolet disinfection lamp" should be affixed to areas with ultraviolet radiation such as logistics windows.